Beilstein J. Org. Chem.2016,12, 2644–2662, doi:10.3762/bjoc.12.261
by inclusion into their hydrophobic cavity, they have been widespread used to develop numerous pharmaceutical formulations. Nevertheless, CDs are also able to interact with endogenoussubstances that originate from an organism, tissue or cell. These interactions can be useful for a vast array of
reviewed as well as their interactions with isolated biomolecules leading to the formation of inclusion or exclusion complexes. Finally, some potential medical applications are highlighted throughout several examples.
Keywords: cellular interactions; cyclodextrins; endogenoussubstances; extraction
complexation of endogenoussubstances are of potential interest for many applications.
Biomolecule/cyclodextrin inclusions complexes
Native and modified CDs can be used to complex certain chemicals produced naturally present in cells and tissues (i.e., endogenoussubstances). Indeed, CDs are able to form
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Graphical Abstract
Scheme 1:
Structure and conventional representation of native CDs.